WebJan 19, 2024 · Lactylation was initially discovered in research on inflammation and immunity, but some clues suggest its involvement in cancer progression. Since the discovery of the Warburg effect by Otto Warburg in 1956 [ 1 ], lactate, a core metabolite produced by the Warburg effect, has attracted increasing attention [ 60 ]. WebOct 24, 2024 · We identify PKM2 as a lactylation substrate and confirm that lactylation occurs mainly at the K62 site. We find that lactate increases the lactylation level of …

Lactate metabolism in human health and disease Signal …

WebJun 10, 2024 · Lactylation in Inflammation. During M1 macrophage polarization, histone lactylation increases in a pattern closely correlated with time , which is a characteristic of M1 macrophages rather than M2 macrophages. This finding emphasizes that active glycolysis is important to the modulation of histone lactylation. WebJan 6, 2024 · Lactylation levels of all proteins and H3K18 from peripheral blood mononuclear (PBMC) were determined by western blotting and serum levels of inflammatory cytokines by flow cytometry. Arginase-1 ( Arg1) and Krüppel-like factor-4 ( Klf4) mRNA expression was evaluated by quantitative real-time PCR (qRT-PCR). copy and paste alphabet fonts

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WebDec 4, 2024 · Inflammation is one of the causes and mechanisms that induce cardiac disorders. In the clearance process of inflammatory infiltration, macrophages express repair genes and reduce inflammatory genes to protect host tissues from impairment. ... Interestingly, lactylation and crotonylation as two novel PTMs that were discovered … WebMar 28, 2024 · Lactylation has been detected in pulmonary fibrosis, which is a potential etiological factor of hypoxic PAH, and the results showed enriched histone lactylation … famous people born on march 26th