WebThe inducible deletion of Irf4 specifi- cally in mature B cells revealed that IRF4 regulates NOTCH2-mediated homing of mature B cells either in MZ or FO compartment of the spleen (Simonetti et al ... WebOct 6, 2024 · Transient expression of IRF4 in B cells induces the expression of BCL-6 and POU2AF1 and promotes GC development 32. IRF4 expression is rapidly induced by BCR …
Transcriptional Regulation of Germinal Center B and Plasma Cell …
WebApr 8, 2024 · These cells showed a downregulation of Pax5 compared to other B cells. Within Blimp-1 + IRF4 + B cells, IgM-, IgG-, and IgA-expressing cells were identified and immunoglobulin-class distribution was clearly different between the anatomical locations, with IgA + PCs dominating in lung tissue and IgM + PCs dominating in the spleen. … WebNov 22, 2024 · IRF4 is also required in B cells for germinal center formation and plasma cell differentiation ( 14 – 16 ). Because of IRF4’s unique role in mature B cells, we … guitar player editor
Simplified algorithm for genetic subtyping in diffuse large B-cell ...
WebIRF4 is a member of the interferon regulatory factor (IRF) family of transcription factors and exerts critical functions in various cell types of the immune system (De Silva et al., 2012).In the B cell lineage, IRF4 is expressed in all developmental stages, with the exception of germinal center (GC) B cells (Falini et al., 2000; Cattoretti et al., 2006). WebMay 16, 2013 · The transcription factor IRF4 regulates immunoglobulin class switch recombination and plasma cell differentiation. Its differing concentrations appear to … WebOnce a B cell is within the quiescent mature follicular (FO) or marginal zone (MZ) pools, these transcriptional programs are maintained at steady state unless activating signals are received. 2. Activation initiates transcriptional program shifts guitar player figurines