WebFeb 1, 2024 · Inclisiran is a double-stranded small interfering ribonucleic acid (siRNA), conjugated on the sense strand with triantennary N-Acetylgalactosamine (GalNAc) to facilitate uptake by hepatocytes. In hepatocytes, inclisiran utilizes the RNA interference mechanism and directs catalytic breakdown of mRNA for PCSK9. HCPCS codes covered if selection criteria are met: J1306: Injection, inclisiran, 1 mg: ICD-10 codes covered if selection criteria are met: E78.01: Familial hypercholesterolemia: I25.10 - I25.119: Atherosclerotic heart disease of native coronary artery: I25.700 - I25.799 See more Note: Requires Precertification: Precertification of inclisiran (Leqvio) is required of all Aetna participating providers and members in applicable plan designs. For precertification of inclisiran (Leqvio), call (866) … See more Leqvio is supplied for injection as 284 mg of inclisiran in 1.5 mL (189 mg/mL) solution in a single-dose prefilled syringe. Leqvio should be … See more
Leqvio: Package Insert / Prescribing Information - Drugs.com
WebLeqvio (inclisiran) is proven and medically necessary for the treatment of heterozygous familial hypercholesterolemia ... Listing of a code in this policy does not imply that the service described by the code is a co vered or non-covered health service. ... HCPCS Code Description J1306 . Injection, inclisiran, 1 mg . Diagnosis Code Description ... WebJan 25, 2024 · mercialize inclisiran under a license and collaboration agree-ment with Alnylam Pharmaceuticals, Inc. [8 ]. 2 Scientic Summary 2.1 Pharmacodynamics Inclisiran is a double-stranded, chemically synthesised siRNA directed against PCSK9 mRNA and conjugated with triantennary GalNAc on the sense strand [1 , 3]. Specic bind- how do you divide in a ratio
National Center for Biotechnology Information
http://ereferrals.bcbsm.com/home/news/home-news-336.shtml WebJan 12, 2024 · The U.S. Food and Drug Administration (FDA) recently approved inclisiran injection (Leqvio) to be used with diet and statin therapy in adults with heterozygous … WebJul 1, 2024 · HCPCS Code: J1306: Description: Long description: Injection, inclisiran, 1 mg Short description: Injection, inclisiran, 1 mg HCPCS Modifier 1: HCPCS Pricing indicator … how do you divide negatives and positives