WebIntroduction: In ALL, minimal residual disease (MRD) is defined as the detection of leukemic cells in bone marrow by PCR or flow cytometry in the presence of hematological complete remission (CR). Patients with persistent/recurrent MRD after induction therapy have a higher risk of relapse than those with no detectable MRD. Web4 okt. 2014 · The hematologic complete response (CR) was achieved in four patients, stable in five and progression in one. The organ response was observed in two patients who, even if temporary, achieved hematologic CR. Hematologic or organ progression after HDM/ASCT occurred in two patients alive.
UPDATED RESULTS FROM PHASE 3 ANDROMEDA STUDY OF PATIENTS WITH …
Web22 okt. 2024 · Of 90 patients with complete remission (CR) or CR with partial hematologic recovery (CRh), 64 (71.1%) achieved a complete MRD response (no detectable individual rearrangements of immunoglobulin/T-cell receptor genes by polymerase chain reaction [PCR] at a minimum sensitivity level of 10-4). Eleven patients had MRD <10-4. Web15 nov. 2024 · Recently, CR with partial hematologic recovery (CRh, blasts 500, Plt >50) has been proposed as a response criteria for patients with acute leukemias, including … nba games on wednesday
Hematologic relapse in AL amyloidosis after high-dose melphalan …
WebPatients receiving ASCT or PI-based therapies were more likely to achieve at least a hematologic CR/VGPR compared to those receiving other therapies: 66% vs 2%, p < 0.0001. Patients that achieved a hematologic CR were more likely to achieve a renal response (53% vs 24%, p = 0.001). Web23 nov. 2024 · Recently, CR with incomplete hematologic improvement (CRh, blasts < 5%, ANC > 500, Plt > 50) has been evaluated as a response in acute leukemias, but its … Web18 jan. 2024 · At our center, we offer ASCT-eligible patients a sequential treatment approach, offering transplant only to subjects who do not attain CR or VGPR after induction. With this strategy, hematologic response rate is high (overall 76%, CR 34%, VGPR 29%), median duration of response is 4.5 years, and TRM is less than 1% [ 62 ]. marlene wright