WebSince CYP17A1 is a key enzyme in the gonadal and extragonadal steroid biosynthesis, abiraterone has a wide spectrum of adverse effects including hypertension, edema, and hypokalemia . The diversion of steroid precursors, as a result of CYP17A1 inhibition, to the mineralocorticoid pathway is responsible for some of these adverse effects [ 5 ]. WebMorusflavone, a flavonoid from Morus alba L., was evaluated for its interactive ability and stability with CYP17A1, in comparison with abiraterone, which is a Food and Drug Administration (FDA)-approved CYP17A1 inhibitor. CYP17A1 inhibition is an important therapeutic target for prostate cancer. The CHAMM36 force field was used to perform …
Exploring the Chemical Space of CYP17A1 Inhibitors Using ...
WebMay 9, 2024 · Objective: To elucidate the relationship between CYP17A1/CYP19A1/SHBG gene polymorphisms and PCOS susceptibility.Methods: We searched multiple databases … fnaf simulator by obsidius
CYP11A1 inhibition as a therapeutic approach for the …
WebMar 21, 2024 · CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP17A1 include Adrenal Hyperplasia, Congenital, Due To 17-Alpha-Hydroxylase … WebMay 22, 2024 · Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for … Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types, including the zona … See more Gene The CYP17A1 gene resides on chromosome 10 at the band 10q24.3 and contains 8 exons. The cDNA of this gene spans a length of 1527 bp. This gene encodes a member … See more Expression of CYP17A1 has been found in all of the traditional steroidogenic tissues except the placenta, including the zona reticularis and zona fasciculata of the adrenal cortex, the Leydig cells of the testes, the thecal cells of the ovaries, and, more recently, in See more CYP17A1 inhibitors Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal scaffold that is similar to the endogenous … See more • Pregnenolone • 17α-Hydroxypregnenolone • Progesterone See more CYP17A1 is a member of the cytochrome P450 superfamily of enzymes localized in the endoplasmic reticulum. Proteins in this family are monooxygenases that catalyze synthesis of See more Mutations in this gene are associated with rare forms of congenital adrenal hyperplasia, specifically 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency. In humans, the CYP17A1 gene is largely associated with … See more • Biology portal • Steroidogenic enzyme • Cytochrome P450 oxidoreductase deficiency See more fnaf sims 4 costumes