WebMay 8, 2024 · Key Points español 中文 (chinese) . Question What are the characteristics and risk factors associated with acute kidney injury among children receiving cisplatin infusions?. Findings In this cohort study of … WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ...
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WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney … WebSep 1, 2024 · Iron might play a critical role in mediating cisplatin-induced kidney injury; however, the association between CIN and ferroptosis remains unclear. In this study, we found that cisplatin induced an increase in renal iron content and that this effect could be prevented by a ferroptosis inhibitor. 2. Materials and methods iisc technical assistant admit card 2022
Biomolecules Free Full-Text Cisplatin-Induced Kidney Toxicity ...
WebMar 27, 2024 · Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the association between AKI after preoperative chemotherapy and postoperative complications in patients with esophageal cancer. Methods WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as injury to the renal vasculature, results in vasoconstriction, reduced blood flow, and ischemic injury. iisc summer research fellowship 2022