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Cisplatin kidney injury

WebMay 8, 2024 · Key Points español 中文 (chinese) . Question What are the characteristics and risk factors associated with acute kidney injury among children receiving cisplatin infusions?. Findings In this cohort study of … WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ...

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WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney … WebSep 1, 2024 · Iron might play a critical role in mediating cisplatin-induced kidney injury; however, the association between CIN and ferroptosis remains unclear. In this study, we found that cisplatin induced an increase in renal iron content and that this effect could be prevented by a ferroptosis inhibitor. 2. Materials and methods iisc technical assistant admit card 2022 https://zohhi.com

Biomolecules Free Full-Text Cisplatin-Induced Kidney Toxicity ...

WebMar 27, 2024 · Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the association between AKI after preoperative chemotherapy and postoperative complications in patients with esophageal cancer. Methods WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as injury to the renal vasculature, results in vasoconstriction, reduced blood flow, and ischemic injury. iisc summer research fellowship 2022

The novel STING antagonist H151 ameliorates cisplatin-induced …

Category:Impact of cisplatin-induced acute kidney injury on long …

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Cisplatin kidney injury

Pathophysiology of cisplatin-induced acute kidney injury

WebThe most direct evidence for NLRP3 involvement in CIN comes from NLRP3-specific inhibitor experiments that showed protection against CIN. Cisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, demonstrating the role of the NLRP3 inflammasome in exacerbating CIN directly . WebThe most direct evidence for NLRP3 involvement in CIN comes from NLRP3-specific inhibitor experiments that showed protection against CIN. Cisplatin-induced kidney injury was mitigated by chemical inhibition of NLRP3 with MCC950, demonstrating the role of the NLRP3 inflammasome in exacerbating CIN directly .

Cisplatin kidney injury

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WebFeb 3, 2024 · Cisplatin, a widely used anticancer agent, can cause nephrotoxicity, including both acute kidney injury (AKI) and chronic kidney diseases, by accumulating in renal tubular epithelial cells (TECs). Mitochondrial pathology plays an important role in the pathogenesis of AKI. WebSep 1, 2004 · Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-dependent Changes in the Absence of Clinical Nephrotoxicity. Clin Pharmacol Ther. 2024 04; 101 (4):510-518. PMID: 28002630. View in: PubMed George B, You D, Joy MS, Aleksunes LM. Xenobiotic transporters and kidney injury. Adv Drug Deliv Rev. 2024 07 …

WebJan 18, 2024 · Background Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI. Methods Japanese patients, who received cisplatin as the first-line chemotherapy at … WebNational Center for Biotechnology Information

WebJan 3, 2024 · Cisplatin-induced acute kidney injury (CI-AKI) is a significant co-morbidity of chemotherapeutic regimens. While this condition is associated with substantially lower survival and increased economic burden, there is no pharmacological agent to effectively treat CI-AKI. The disease is hallmarked by acute tubular necrosis of the proximal tubular … 1. Introduction. Acute kidney injury (AKI) is defined as a clinical syndrome …

WebWhile the pathogenesis of cisplatin-induced kidney injury is complex, the major underlying mechanisms converge on oxidative stress, inflammation, and renal fibrosis [ 11, 17 ], which may involve major NAD + -dependent redox enzymes, such as mitochondrial complex I, CD38, NNT, NADK, PARP, alpha-keto acid dehydrogenases, and sirtuins.

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). iisc swimming poolWebJan 28, 2024 · A major adverse consequence of cisplatin therapy is acute kidney injury (AKI). It is reported that between 30 and 38 percent of patients develop signs of nephrotoxicity (toxicity in the kidneys) after a single cisplatin dose, despite strategies such as hydration to limit renal exposure. This is problematic for patients as kidney injury can ... iisc technical assistantWebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. iisc technical assistant application login